In general, I have found that a discussion about an optimal setting usually only results in starting over and over again.
While Dave's Files are a great thing, it makes you wonder if you're not missing out on something with every new update if you're not playing with the latest version.
This also applies to the optimal setups. You're practically persuaded to start over because these setups and these files are just fine. But, that means you never get a long-term save. Because the optimal setup also contains a plethora of players.
If you really want to enjoy the game, you should just start and not worry so much (although I do it again and again and it makes me sick ^^) about a better setting.
No criticism, just my opinion :)