Click on the playing time view on squad screen and change playing time agreements to level on actual playing time or lower. Better chance of not creating any problems if the team is doing well.
Set reminders through notes like contract renewals, praising training & conduct, scouting free transfers etc.
Check data hub -> analyst report to see potential weak spots in upcoming opposition tactic
Use search filters on statistics (key passes, dribbles, interceptions etc) based on averages on the level you want your team to play
Rotate your team against weaker sides especially if injury risk is high and match load heavy on your regular players
Use the next match only for tactical tweaks and player changes
Don't be afraid to sell rotation options if and especially you have a competent replacement in the youth system