Now whilst the normal drive to install the game on is C:\ I have a quaestion

I have a 2nd drive which is E:\ which is pretty much empty. Now what I want to know is, am I able to install FM10 on this E:\ ? and how would it impact the game ? would it run alot better since the drive is pretty much empty ? Will it run at all on the E:\ ??

If I can use it on the E:\ how much different during installation of FM10 would it be ? whould I have to do anythng different ??

Many thanks ahead of time for this help. I hope to be getting the game int he next couple of days